Table 2. Pooled diagnostic test characteristics of preoperative biomarkers for the prediction of LNM.

^aReferences can be found in supplemental online Appendix 3.

^bThis value is extracted from the study with the median prevalence of LNM. Range includes the minimum and maximum prevalence.

^cPooled PPVs and NPVs were estimated using a median prevalence of lymph node metastasis (13.4%).

^dFor these variables, included studies used different definitions of a positive test result. These can be found in Table 1.

^eFor these biomarkers, no subgroup analysis was performed because of small study numbers.

Abbreviations: ¹⁸FDG PET‐CT, ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography; AUC, area under the curve; BMI, body mass index; Ca‐125, cancer antigen 125; CI, confidence interval; CT, computed tomography; LNM, lymph node metastasis; LR, likelihood ratio; MRI, magnetic resonance imaging; NPV, negative predictive value; PPV, positive predictive value.