Table 2. Genotype and allele frequencies of ADAMTS7 variants between IS patients and controls, and corresponding ORs for IS.
| Genotype & Allele | Initial cohort | Replication cohort | Combined cohort | |||||||
| IS patients (n=615) | Controls (n=615) | OR (95% CI) | P valuea | IS patients (n=664) | Controls (n=653) | OR (95% CI) | P valuea | OR (95% CI) | P valuea | |
| rs3825807 | ||||||||||
| AA | 462(75.1) | 412(67.0) | 0.0073 | 492(74.4) | 443(67.8) | 0.037 | 2.4×10-4 | |||
| AG | 140(22.8) | 181(29.4) | 158(23.8) | 187(28.7) | ||||||
| GG | 13(2.1) | 22(3.6) | 14(1.8) | 23(3.5) | ||||||
| AA vs AG/GG | 153(24.9) | 203(33.0) | 0.67(0.52-0.86) | 0.0040 | 172 (25.9) | 210 (32.2) | 0.74(0.58-0.94) | 0.024 | 0.71(0.59-0.84) | 1.3×10-4 |
| AA/AG vs GG | 602(97.9) | 593(96.4) | 0.58(0.29-1.17) | 0.17 | 650 (97.9) | 630 (96.5) | 0.59(0.30-1.16) | 0.11 | 0.59(0.36-0.95) | 0.031 |
| A | 1064(86.5) | 1005(81.7) | 1142(86.0) | 1073(82.2) | ||||||
| G | 166(13.5) | 225(18.3) | 0.70(0.56-0.87) | 0.0040 | 186 (14.0) | 233 (17.8) | 0.75(0.61-0.93) | 0.024 | 0.72(0.62-0.84) | 1.2×10-4 |
| rs11634042 | ||||||||||
| CC | 464(75.4) | 415(67.5) | 0.0071 | 496(74.7) | 448(68.6) | 0.035 | 2.0×10-4 | |||
| CT | 139(22.6) | 178(28.9) | 155(23.3) | 182(27.9) | ||||||
| TT | 12(2.0) | 22(3.6) | 13(2.0) | 23(3.5) | ||||||
| CC vs CT/TT | 151(24.6) | 200(32.5) | 0.68(0.53-0.87) | 0.0048 | 168(25.3) | 205(34.5) | 0.75(0.59-0.95) | 0.026 | 0.71(0.60-0.84) | 1.8×10-4 |
| CC/CT vs TT | 603(98.0) | 593(96.4) | 0.54(0.26-1.09) | 0.12 | 651(98.0) | 630(96.5) | 0.55(0.27-1.09) | 0.077 | 0.54(0.33-0.89) | 0.015 |
| C | 1067(86.7) | 1008(82.0) | 1147(86.4) | 1078(82.5) | ||||||
| T | 163(13.3) | 222(18.0) | 0.69(0.56-0.86) | 0.0048 | 181(13.6) | 228(17.5) | 0.75(0.60-0.92) | 0.026 | 0.72(0.62-0.84) | 1.0×10-4 |
| rs4380028 | ||||||||||
| CC | 211(34.3) | 188(30.6) | 0.48 | 233(35.1) | 207(31.7) | 0.27 | 0.14 | |||
| CT | 296(48.1) | 309(50.2) | 316(47.6) | 314(48.1) | ||||||
| TT | 108(17.6) | 118(19.2) | 115(17.3) | 132(20.2) | ||||||
| CC vs CT/TT | 404(65.7) | 427(69.4) | 0.84(0.66-1.07) | 0.38 | 431(64.9) | 446(68.3) | 0.86(0.68-1.08) | 0.25 | 0.85(0.72-1.00) | 0.12 |
| CC/CT vs TT | 507(82.4) | 497(80.8) | 0.90(0.67-1.20) | 0.51 | 549(82.7) | 521(79.8) | 0.83(0.63-1.09) | 0.25 | 0.86(0.70-1.05) | 0.14 |
| C | 718(58.4) | 685(55.7) | 782(58.9) | 728(55.7) | ||||||
| T | 512(41.6) | 545(44.3) | 0.90(0.76-1.05) | 0.38 | 546(41.1) | 578(44.3) | 0.88(0.75-1.03) | 0.25 | 0.89(0.79-0.99) | 0.12 |
| rs7173743 | ||||||||||
| TT | 166(27.0) | 135(22.0) | 0.013 | 186(28.0) | 152(23.3) | 0.025 | 2.5×10-4 | |||
| TC | 309(50.2) | 297(48.3) | 330(49.7) | 315(48.2) | ||||||
| CC | 140(22.8) | 183(29.7) | 148(22.3) | 186(28.5) | ||||||
| TT vs TC/CC | 449(73.0) | 480(78.0) | 0.76(0.59-0.99) | 0.046 | 478(72.0) | 501(76.7) | 0.78(0.61-1.00) | 0.047 | 0.77(0.64-0.92) | 0.0046 |
| TT/TC vs CC | 475(77.2) | 432(70.3) | 0.70(0.54-0.90) | 0.013 | 516(77.7) | 467(71.5) | 0.72(0.56-0.92) | 0.020 | 0.71(0.59-0.85) | 2.5×10-4 |
| T | 641(52.1) | 567(46.0) | 702(52.9) | 619(47.4) | ||||||
| C | 589(47.9) | 663(54.0) | 0.79(0.67-0.92) | 0.012 | 626(47.1) | 687(52.6) | 0.80(0.69-0.94) | 0.020 | 0.79(0.71-0.89) | 1.7×10-4 |