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. 2019 Aug 16;11(16):6109–6119. doi: 10.18632/aging.102169

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Copyright © 2019 Zou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 3.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Gene modules and functional enrichment. (A) Gene modules and related genes. The green node indicates the module; red, genes upregulated in AD; blue, genes downregulated in AD. (B) Differentially expressed genes in each module. (C) GO Enrichment Analysis. Enrichment increases significantly going from blue to red. The larger the circle, the more significant the proportion of module genes present among GO functional entry genes. (D) Enrichment analysis of KEGG pathway of the module gene. From blue to red, the enrichment increases significantly. The larger the circle, the more significant the proportion of module genes present among KEGG pathway entry genes.