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. 2019 Jul 26;18(18):2293–2306. doi: 10.1080/15384101.2019.1644913

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Figure 1. — Analysis of the expression of INK4 family genes in kidney cancer.

(A) Transcriptional analysis using UALCAN showed that CDKN2A and CDKN2B were upregulated in the tumor tissues, while CDKN2C and CDKN2D were downregulated. INK4 family genes: CDKN2A (cyclin dependent kinase inhibitor 2A), CDKN2B (cyclin dependent kinase inhibitor 2B), CDKN2C (cyclin dependent kinase inhibitor 2C), and CDKN2D (cyclin dependent kinase inhibitor 2D). KIRC: kidney renal clear cell carcinoma. (B) Expression of INK4 family genes at different stages of kidney cancer. CDKN2A, CDKN2B, CDKN2C, and CDKN2D are highly expressed in the late stage of tumor development. (C) The examination of a potential correlation between INK4 family genes and the prognosis of patients with kidney cancer. Kaplan-Meier plots showing overall survival, with patients with expression levels above the median indicated in red and those below indicated in black. These plots revealed a correlation between these genes and the overall survival rate. Expressional changes in INK4 family genes in cancerous tissues and adjacent tissues from patient samples as detected by (D) fluorescence-based qRT-PCR, (E) immunohistochemistry, and (F) Western blot.