Figure 4.

INK4 family genes can inhibit the formation and development of kidney cancer.

(A) The INK4 family genes, including CDKN2A, CDKN2B, CDKN2C, and CDKN2D, were upregulated in OSRC cells, with these cells injected subcutaneously into nude mice for in vivo experimentation. (B) After eight weeks later, the subcutaneous tumor was removed and the volume was measured. (C) INK4 family gene expression in subcutaneous tumors. (D) The weight was also measured after eight weeks. (E) Cyclin D1 expression in subcutaneous tumors with altered INK4 family gene expression. (F) CDK4 expression in subcutaneous tumors with altered INK4 family gene expression.