Figure 4.

Upregulated miR-140-5p represses inflammation reaction of rats with KOA. a, the expression of IL-1β and TNF-α in the serum and synovial tissues of each group was detected by ELISA; b, the expression of IL-1β and TNF-α of synovial tissues was detected by RT-qPCR; * P < 0.05 vs the control group, # P < 0.05 vs the ACLT group. N = 10, * P < 0.05 vs the control group, # P < 0.05 vs the ACLT group. The measurement data conforming to the normal distribution were expressed as mean ± standard deviation. ANOVA was used for comparisons among multiple groups. Tukey’s multiple comparisons test was used for pairwise comparisons after ANOVA.