Figure 10.

Upregulated miR-140-5p represses activation of TLR4/Myd88/NF-κB pathway in synoviocytes of rats with KOA. a, the expression of TLR4, Myd88 and NF-κB was detected by RT-qPCR; b, protein bands of TLR4, Myd88 and NF-κB; c, the statistical results of expression of TLR4, Myd88 and NF-κB in the cells of each group by Western blot analysis; * P < 0.05 vs the normal group, # P < 0.05 vs the ACLT group. The experiment was repeated for three times. The measurement data conforming to the normal distribution were expressed as mean ± standard deviation. ANOVA was used for comparisons among multiple groups. Tukey’s multiple comparisons test was used for pairwise comparisons after ANOVA.