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. 2019 Jul 26;114(9):1502–1511. doi: 10.14309/ajg.0000000000000327

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

Open Access This article is licensed under a Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://crealrvecommons.org/licenses/by-nc-nd/4.0/.

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Figure 2. — Weekly composite responder during the 12-week treatment period, and for at least 6 weeks out of 12 weeks from weeks 1–12 by 2 definitions. Definition #1 = weekly composite responder is defined as daily composite responder on ≥4 days for a week. Daily composite responder = WAP improvement by ≥40% compared with baseline and BSS score <5 (or the absence of bowel movement if accompanied by ≥40% improvement in WAP) compared to baseline. Definition #2 = weekly composite responder is defined as patients with weekly average WAP improvement of ≥40% from average WAP of the baseline week and with ≥50% reduction in the days of BSS score 6/7 for a week comparing with days of BSS score 6/7 during the baseline week. BSS, Bristol Stool Scale; WAP, worst abdominal pain. P-values are based on χ² test.