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. 2019 Jul 26;114(9):1502–1511. doi: 10.14309/ajg.0000000000000327

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

Open Access This article is licensed under a Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://crealrvecommons.org/licenses/by-nc-nd/4.0/.

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Figure 3. — Analysis of pain and stool consistency responders. (a) Monthly pain responders (i.e., patients who met the daily pain response criteria for ≥50% of days with diary entries over a certain time period, defined for the full 12-week treatment period [≥60 days of diary entries for the full 12 weeks] and each 4-week interval [>20 days of diary entries for each 4-week interval] as ≥40% improvement in WAP compared with baseline). Analysis of responders who met the daily (b) 30% and (c) 50% improvement in WAP. (d) Analysis of monthly stool consistency responders (i.e., patients who met the daily stool consistency for ≥50% of days with diary entries over a certain time period, defined for the full 12-week treatment period [≥60 days of diary entries for the full 12 weeks] and each 4-week interval [>20 days of diary entries for each 4-week interval]) compared with baseline. WAP, worst abdominal pain. P-values are based on χ² test.