TABLE 2.

Carotid artery intima-media thickness (CIMT) before (baseline) and at exit from KEEPS (48 mo)^a

	Baseline		48 mo
Treatment	n	Mean CIMT (95% CI), mm	n	Mean CIMT (95% CI), mm	Estimated changeb in CIMT (95% CI), mm/y
Placebo	275	0.7213 (0.7106-0.7319)	217	0.7502 (0.7388-0.7619)	0.0072 (0.0058-0.0086)
o-CEE	230	0.7268 (0.7152-0.7384)	185	0.7591 (0.7465-0.7717)	0.008 (0.0065-0.0095)
t-E2	222	0.7176 (0.7058-0.7294)	178	0.7488 (0.7359-0.7616)	0.0077 (0.0061-0.0092)

o-CEE, oral conjugated equine estrogens; t-E₂, transdermal 17-β estradiol.

^aDerived from Table 2 of reference 7.

^bChange between baseline and 48 months as annual slope.