Table 1.
Histological scores: WT and TRIF mutant mice were infected with 1 × 104 CFU K. pneumoniae and 50 ng recombinant IFN-γ was administered intranasally upon infection and after 48 h
| WT vehicle | WT rIFN-γ | TRIF mutant vehicle | TRIF mutant rIFN-γ | |
|---|---|---|---|---|
| Total pathology score: lung | 14.5 (0.6) | 13.8 (0.8) | 14.5 (1.2) | 13.1 (0.6) |
| Pneumonia % of lung surface | 15 (3) | 6 (4) | 22 (6) | 7 (3) |
| Interstitial inflammation | 3.1 (0.1) | 3.0 (0.5) | 2.8 (0.7) | 2.4 (0.3) |
| Edema | 2.8 (0.2) | 2.5 (0.3) | 3.4 (0.5) | 3.0 (0.2) |
| Endothelialitis | 2.5 (0.2) | 2.9 (0.1) | 3 (0.2) | 2.6 (0.2) |
| Bronchitis | 2.9 (0.1) | 3.5 (0.2)* | 2.6 (0.3) | 3.8 (0.2)# |
| Pleuritis | 1.8 (0.3) | 1.3 (0.2)* | 1.5 (0.3) | 0.8 (0.2)# |
| Ly-6-positive % of total lung surface | 2.3 (0.4) | 2.1 (0.5) | 8.6 (1.2)** | 3.9 (0.8)# |
Total pathology score is the sum of the histological subscores (determined as described in Methods). Data are mean (SE) of 7–8 mice per group.
*
p <0.05,
**
p <0.01, vs. vehicle-treated WT mice.
#
p <0.05, rIFN-γ-treated TRIF mutant mice vs. vehicle-treated TRIF mutant mice.