Table 2.

Inflammatory response

	WT Vehicle	WT rIFN-γ	TRIF mutant vehicle	TRIF mutant rIFN-γ
TNF-α	892 (245)	760 (57)	191 (48)**	501 (115)#
IL-1β	7,434 (642)	4,950 (753)*	4,168 (731)**	4,525 (557)**
IL-6	1,914 (451)	2,030 (624)	2,446 (398)	1,507 (216)#
IL-10	14 (2)	11 (1)	14 (2)	b.d.
CXCL1	12,586 (1,899)	9,453 (1,645)	3,625 (871)**	4,255 (828)*
CXCL2	20,553 (6,546)	38,048 (7,157)	6,432 (1,532)*	28,943 (5,785)###
CCL2	4,619 (541)	3,718 (366)	1,841 (210)***	2,126 (240)**' #

WT and TRIF mutant mice were infected with 1 × 104 CFU K. pneumoniae and 50 ng recombinant IFN-γ was administered intranasally upon infection and after 48 h. Homogenates were prepared from right lungs. Cytokine and chemokine levels are presented in pg/ml of lung homogenate. Data are mean (SE) of 7–8 mice per group. b.d. = Below detection.

^*p <0.05,

^**p <0.01,

^***p <0.001, vs. vehicle-treated WT mice.

^#p <0.05,

## p <0.01,

^###p <0.001, rIFN-γ-treated TRIF mutant mice vs. vehicle-treated TRIF mutant mice.