Fig. 1.

P2X7KO mice have significantly reduced sensitivity to sepsis induced by CLP. a Animal survival was monitored for 7 days after CLP and a Kaplan-Meier analysis of the number of animals at risk of death was performed. Blood samples and peritoneal washes were collected from animals 24 h after sepsis induction by CLP, and the number of bacterial CFU was estimated in blood samples (b), while the total number of cells was estimated in peritoneal washes (c). * p ≤ 0.05: statistically significant difference between treated and control groups (e.g. WT CLP vs. WT Sham); # p ≤ 0.05: statistically significant difference between mouse strains (e.g. WT CLP vs. P2X7KO CLP). Charts represent results from 5 independent experiments (n = 5 mice per group) and the survival curve represents results from 3 independent experiments (n = 10 mice per group).