Fig. 4.

The induction of proinflammatory cytokine production in the peritoneum was reduced in P2X7KO mice after sepsis induced by CLP. Levels of the proinflammatory cytokines IL-1β (a), TNF-α (b), IL-6 (c), IL-17 (d), IL-12 (e), and IL-4 (f) in peritoneal washes collected 24 h after CLP were estimated by ELISA. * p ≤ 0.05: statistically significant differences between treated and control groups (e.g. WT CLP vs. WT Sham); # p ≤ 0.05: statistically significant difference between mouse strains (e.g. WT CLP vs. P2X7KO CLP). Graphs represent results from 3 independent experiments (n = 5 mice per experiment).