Fig. 5.

Production of anti-inflammatory cytokines is impaired in P2X7KO mice after sepsis induction by CLP. The levels of the anti-inflammatory cytokines TGF-β (a) and IL-10 (b) in peritoneal washes collected 24 h after CLP were measured by ELISA. * p ≤ 0.05: statistically significant difference between treated and control groups (e.g. WT CLP vs. WT Sham); # p ≤ 0.05: statistically significant difference between mouse strains (e.g. WT CLP vs. P2X7KO CLP). Graphs represent results from 3 independent experiments (n = 5 mice per experiment).