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. 2015 Feb 14;7(4):392–404. doi: 10.1159/000374115

Fig. 1.

Fig. 1

IL-17A from DNCB-treated K14.E7 transgenic skin contributes to the induction of arginase in BMDMs. a C57BL/6, K14.E7, Rag−/- and E7.Rag−/- mice were treated with vehicle or DNCB for 4 h. Explanted skin was cultured for 24 h and culture supernatant was assessed for induction of BMDM arginase activity. b Arginase activity in BMDMs cultured in vehicle or DNCB-treated K14.E7 skin explant supernatants and exposed to isotype-matched antibodies or neutralising antibodies (10 ng/ml) against IL-4, IL-10 or IL-17A. c Arginase activity in BMDMs cultured in supernatants from vehicle or DNCB-treated E7.IL17−/- or E7.IL17+/- skin explants. Data are means ± SEM and are representative of two independent experiments, each with 4–6 mice/group. * p < 0.05, ** p < 0.01. n.s. = Non-significant.