Table 1.
Complement anaphylatoxin functions
| Function | C3a | C4a | C5a | Reference |
|---|---|---|---|---|
| Defined receptor | + | _ | + | 3, 4, 29–31 |
| Chemotaxis | + | ? | + | 3, 4, 13, 32, 33 |
| Smooth-muscle contraction | + | ? | 3, 4, 13, 34 | |
| Vascular permeability | + | ? | + | 34, 35 |
| Myeloid cell activation | + | – | + | 3, 4, 13, 36 |
| Platelet activation | + | – | + | 3, 4, 13, 37, 38 |
| CD4/CD8 and γδ T cell modulation | + | – | + | 39–44 |
| Induction of acute phase response (cytokine production) | + | – | + | 3, 4, 13, 45 |
| Developmental homing | + | – | + | 46–49 |
| Regeneration | + | – | + | 1, 2, 50, 51 |
| Antimicrobial | + | + | – | 27, 52–54 |
| Cross-desensitization | ? | 55, 56 |