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An illustration showing the deposition of the OmpU-IgG-C1q complex on a bacterial cell surface and OMV-mediated protection against OmpU-IgG-C1q-dependent serum killing. a IgG-C1q complex binding to OmpU protein of bacterial outer membrane leads to a complement-mediated serum killing effect. b OmpU-associated OMVs released from the bacterial cell can bind C1q through IgG leading to the inactivation of serum killing. OM = Outer membrane.
