Fig. 3.

Bacterial loads in WT, gzmA^−/−, gzmB^−/− and gzmAxB^−/− mice during K. pneumoniae pneumonia. Mice were infected with 4 × 10³ CFU K. pneumoniae intranasally. To determine bacterial loads in the lungs (a), blood (b), spleen (c) and liver (d), mice were sacrificed at 6, 16 and 48 h after infection. Box-and-whisker diagrams depict the smallest observation, lower quartile, median, upper quartile and largest observation (n = 7-8 per group at each time point). Dashed lines represent the lower detection limit of CFU. * p < 0.05 (Mann-Whitney U test).