Fig. 1.

Unc93b1-mediated immune activation is protective during acute CVB3 infection. a Survival of Unc93b1^+/+ mice (black circles, solid line) and Unc93b1^Letr/Letr mice (white circles, dashed line; n ≥27 in each group). Viral load in the heart (b), liver (c) and spleen (d) at days 2, 4 and 8 after infection in Unc93b1^+/+ mice (black circles) and Unc93b1^Letr/Letr mice (white circles; n ≥7 in each group). Data are representative of 2 independent experiments. *** p < 0.001, log-rank test (a) or 2-tailed unpaired Student's t test (b-d).