Table 1.
Significant term enrichment following CVB3 infection in the heart
| Term | Genes | Fold enrichment | padj value |
|---|---|---|---|
| Significantly enriched terms in Unc93b1+/+ hearts at day 2 | |||
| Antigen processing and presentation of exogenous peptide antigen via MHC class II | |||
| GO:0019886 | H2-EB1, H2-AA, H2-AB1, CD74 | 92.3 | 3.43E-03 |
| MHC class II protein complex | |||
| GO:0042613 | H2-EB1, H2-AA, H2-AB1 | 125.23 | 1.39E-02 |
| Intestinal immune network for IgA production | |||
| mmu04672 | H2-EB1, H2-AA, H2-AB1, CXCL12 | 21.18 | 2.56E-02 |
| Asthma | |||
| mmu05310 | H2-EB1, H2-AA, H2-AB1 | 27.38 | 4.27E-02 |
| Systemic lupus erythematosus | |||
| mmu05322 | C8B, H2-EB1, H2-AA, H2-AB1 | 11.64 | 4.77E-02 |
| Significantly enriched terms in Unc93b1Letr/Letr hearts at day 2 | |||
| Inflammatory response | |||
| GO:0006954 | CCL11, SERPINA3N, MYD88, SAA1, SPHK1,CXCL9, TLR3, C2, IDO1, LBP, CXCL10 | 6.70 | 1.06E-03 |
| TLR signaling pathway | |||
| mmu04620 | FOS, MYD88, IFNB1, CXCL9, TLR3, LBP, CXCL10 | 8.93 | 7.23E-03 |