Fig. 1.

Survival curves and plasma IL-6 levels in the septic shock patients by the genotype of the VPS13D rs6685273 polymorphism. a, b Patients with the VPS13D rs6685273 CC genotype (solid line) had a significantly increased risk of death over 28 days [p = 0.027 (European ancestry), p = 0.011 (all ethnicities), TT/TC vs. CC genotype]. The log-rank test was used to calculate p values. c Plasma IL-6 levels between survivors and nonsurvivors. Nonsurvivors had increased plasma IL-6 levels compared to survivors (p = 0.0010). d Plasma IL-6 levels by VPS13D rs6685273 genotype. There was a nonsignificant trend for higher plasma IL-6 levels in patients with the CC genotype (TT vs. TC vs. CC genotype, p = 0.26, one-way ANOVA). Plasma IL-6 levels were log-transformed and analyzed. The Student t test or one-way ANOVA was used to calculate p values. Data are the mean ± SEM.