Table 2.
Baseline characteristic of septic shock patients of European ancestry by VPS13D rs6685273 genotype TT/TC (n = 101) CC (n = 397) p value
| Age, years | 59.3 (50.6 - 71.7) | 64.4 (51.1 - 73.6) | 0.12 |
|---|---|---|---|
| Males, n (%) | 60 (59.4) | 241 (60.7) | 0.81 |
| APACHE II | 24 (l9 - 29) | 26 (22 - 32) | 0.0044 |
| urgical, n (%) | 26 (25.7) | 89 (22.4) | 0.48 |
| Vasopressin use, n (%) | 52 (51.5) | 200 (50.4) | 0.84 |
| Physiologic dose steroid use, n (%) | 54 (53.5) | 216 (54.4) | 0.87 |
| Preexisting conditions, n (%) | |||
| Chronic heart failure | 7 (6.9) | 33 (8.3) | 0.65 |
| Chronic pulmonary disease | 14 (l3.9) | 76 (19.1) | 0.22 |
| Chronic liver disease | 10 (9.9) | 44 (11.1) | 0.73 |
| Chronic renal failure | 7 (6.9) | 42 (10.6) | 0.27 |
| Chronic corticosteroid use | 20 (19.8) | 80 (20.2) | 0.94 |
| Physiologic variables on day 1 | |||
| Body temperature, ° C | 38.4 (37.7 - 39.1) | 38.5 (37.6 - 39.2) | 0.79 |
| Heart rate, bpm | 128 (m - 140) | 126 (110 - 140) | 0.99 |
| Mean arterial pressure, mm Hg | 57 (50 - 63) | 55 (50 - 61) | 0.31 |
| Heart rate, bpm | 14 (10 - 18) | 14 (11 - 18) | 0.38 |
| Laboratory variables on day 1 | |||
| White blood cell count, 103/mm3 | 15.3 (8.2 - 24.0) | 15.8 (8.1 - 21.1) | 0.29 |
| Platelet count, 103/mm3 | 152 (82 - 260) | 172 (96 - 257) | 0.54 |
| PaO2/FiO2, mm Hg | 199 (161 - 276) | 189 (135 - 244) | 0.022 |
| Blood creatinine, μmol/l | 108 (70 - 190) | 153 (94 - 249) | 0.0003 |
| Blood lactate, mmol/l | 2.1 (1.4 - 3.6) | 2.2 (1.4 - 4.4) | 0.34 |
Data are given as the median (interquartile range) for continuous variables. p values were calculated with the use of the Mann-Whitney U test and the χ2 test. APACHE = Acute physiology and chronic health evaluation.