Table 3.
Cox regression analysis of mortality up to day 28 (time of censoring) in patients with NSTI based on high versus low concentrations of the biomarkers according to median baseline values
| Unadjusted |
Adjusted for age, sex, chronic disease |
Adjusted for age, sex, chronic disease, SAPS IIa |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| MBL | |||||||||
| High (>627.3 ng/ml) | 1 | 1 | 1 | ||||||
| Low (≤627.3 ng/ml) | 2.25 | 0.92 – 5.52 | 0.077 | 2.23 | 0.91 – – 5.48 | 0.080 | 2.64 | 1.01 – 6.92 | 0.048 |
| Ficolin-1 | |||||||||
| High (>322.3 ng/ml) | 1 | 1 | 1 | ||||||
| Low (≤322.3 ng/ml) | 0.98 | 0.43 – 2.27 | 0.969 | 0.85 | 0.36 – 2.01 | 0.713 | 0.67 | 0.27 – 1.70 | 0.404 |
| Ficolin-2 | |||||||||
| High (>2.9 µg/ml) | 1 | 1 | 1 | ||||||
| Low (≤2.9 µg/ml) | 5.01 | 1.70 – 14.83 | 0.004 | 4.73 | 1.59 – 14.07 | 0.005 | 2.14 | 0.65 – 7.04 | 0.209 |
| Ficolin-3 | |||||||||
| High (>15.0 µg/ml) | 1 | 1 | 1 | ||||||
| Low (≤15.0 µg/ml) | 3.56 | 1.31 – 9.65 | 0.013 | 3.42 | 1.26 – 9.29 | 0.016 | 2.67 | 0.83 – 8.48 | 0.099 |
| Optimal Ficolin-2 cut-offb | |||||||||
| High (>1.9 µg/ml) | 1 | 1 | 1 | ||||||
| Low (≤1.9 µg/ml) | 6.68 | 2.46 – 18.14 | <0.0001 | 6.27 | 2.28 – 17.21 | <0.0001 | 3.16 | 1.03 – 9.73 | 0.045 |
a
Five patients were not included in the analysis due to missing data of SAPS II.
b
Found by maximum sum of sensitivity (0.77) and specificity (0.70).