FIGURE 2.

Tacrolimus dose, trough levels, and concentration-to-dose ratio after antibiotic administration. Box-and-Whisker plots with day on the x-axis and (A) tacrolimus dose, (B) tacrolimus trough, or (C) tacrolimus concentration-to-dose ratios on the y-axis in the 48 subjects who received antibiotics in the first mo of transplantation and had tacrolimus trough before the first antibiotic exposure. In each Box-and-Whisker plot, the horizontal line within each box represents the median, the bottom and top of each box represents the 25th and 75th percentile values, the top whisker represents the 75th percentile value plus 1.5 times the interquartile range, and the bottom whisker represents the 25th percentile value minus 1.5 times the interquartile range. Pre-Abx day refers to the day on or immediately before the first antibiotic exposure. Values below each plot for pre-Abx day, post-Abx day 7, and post-Abx day 15 are presented as medians. Statistical comparisons were made using Wilcoxon signed-rank test.