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. 2019 Sep 11;5(9):eaaw7781. doi: 10.1126/sciadv.aaw7781

Fig. 5. mDUX induces H3 acetylation that is p300 dependent.

Fig. 5

(A) Western blot analyses for H3K18 and H3K27 acetylation in LHCN-imDux and iC2C12-imDux cells continually induced with dox (200 ng/ml) and treated with 0.25 μM iP300w for 12 hours. (B) RT-qPCR for mDux target genes in LHCN-mDux after 12-hour induction with dox (200 ng/ml) and 0.25 μM iP300w. Data are presented as means ± SEM; ****P < 0.001 by one-way ANOVA with Tukey’s post hoc test. Results are presented as relative expression to GAPDH (n = 3). (C) RT-qPCR for mDux target genes in iC2C12-mDux cells after 12-hour induction with dox (200 ng/ml) and 0.25 μM iP300w (n = 3).