FIG 5.

Eight hundred seventeen putative Acr-Aca loci are found in 14 bacterial classes and inferred to target 10 CRISPR-Cas subtypes. The bubble plot shows the phylum-class versus the CRISPR-Cas subtype of the 817 Acr-Aca loci supported by the existence of self-targeting spacers in the genomes. The circle size and color are coded in proportion to the number of loci in that circle (in logarithmic scale). The subtype of Acr-Aca loci is inferred from the CRISPR-Cas self-targeting spacers reported in the paper by Watters et al. (12).