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. Author manuscript; available in PMC: 2020 Sep 30.
Published in final edited form as: Arch Biochem Biophys. 2019 Aug 22;673:108078. doi: 10.1016/j.abb.2019.108078

Table 3.

Inhibitors of human CYP3A7 activity.

Inhibitor Substrate reaction Reference
Triacetyloleandomycin N-demethylation [19]
α-naphthoflavone Imipramine N-demethylation [19]
Troleandomycin all-trans-retinoic acid 4-hydroxylation [62]
Estradiol Carbamazepine 10,11-epoxidation [32]
Triazolam Testosterone 6β-hydroxylation [68]
Amprenavir Testosterone 6β-hydroxylation [36]
Indinavir Testosterone 6β-hydroxylation [36]
Nelfinavir Testosterone 6β-hydroxylation [36]
Ritonavir Testosterone 6β-hydroxylation [36]
Saquinavir Testosterone 6β-hydroxylation [36]
Azamulin 7-benzyloxy-4-trifluoromethylcoumarin [88]
Ketoconazole 7-benzyloxy-4-trifluoromethylcoumarin [87,88]
Δ9-tetrahydrocannabinol Diltiazem N-demethylation [76]
Cannabidiol Diltiazem N-demethylation [76]
Cannabinol Diltiazem N-demethylation [76]
Olivetol Diltiazem N-demethylation [76]
Hop-Containing products Dibenzylfluorescein, 7-ethoxy-3-cyanocoumarin, 7-methoxy-4-trifluoromethylcoumarin [89]
West African medicinal and food plants Dibenzylfluorescein [90]
Melatonin products NA [91]
Astemizole
Cisapride
Clotrimazole
Cyclosporine A
Erythromycin
Ketoconazole
Mibefradil
Midazolam
Nicardipine
Nifedipine
Nimodipine
Terfenadine
Troleandomycin
Verapamil
7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation [92]
*

NA, not available.