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. Author manuscript; available in PMC: 2020 Sep 30.
Published in final edited form as: Arch Biochem Biophys. 2019 Aug 22;673:108078. doi: 10.1016/j.abb.2019.108078

Table 6.

Alleles of CYP3A7.

Allele Protein SNPa Position Effect Ethnic and frequency
%		 Reference
CYP3A7*1A CYP3A7.1, CYP3A7.1L None [12,46]
CYP3A7*1B CYP3A7.1 −211 C > T Promoter Increased expression Brazilian, 0.4
Caucasians, 1.0
African Americans, 0		 [151]
[47,152]
[152]
CYP3A7*1C CYP3A7.1 −186G > T; −179T > A; −177T > C; −176A > T; −165T > G; −157T > A; −127 A > C Promoter Increased expression Brazilian, 1.2–3.3
Caucasians, 2.7–3.9
African Americans, 6.0
Korean, 0
Jordanian, 1.7
Samples Brussels, 4
Liver samples from UK, 6		 [136,151]
[47,77,139,143,144,152]
[152]
[153]
[154]
[155]
[156]
CYP3A7*1D CYP3A7.1 +13 G > A +13 Brazilian, 0.4
Caucasian, 1
African Americans, 0		 [151]
[47,152]
[152]
CYP3A7*1E CYP3A7.1 +55 G > A +55 Brazilian,2.2
Fetal livers, 3.7
African Americans, 8
Caucasians, 0
Caucasian-Americans, 2.6		 [151]
[60]
[153]
[152,153]
[60]
CYP3A7*2 CYP3A7.2 26041C > G Exon 11 T409R Koreans, 26.0
Caucasians, 8.0–10.5
Tanzanians, 62.0
Chinese, 28
Saudi Arabian, 17
Brazilian, 25
Fetal livers, 37.8		 [153]
[53,157]
[53]
[53]
[53]
[151]
[60]
CYP3A7*3 CYP3A7.3 4011insT Exon 2 Frameshift Korean, 0.21 [153]
a

The numbers are relative to the transcription start site in the CYP3A7 gene, which is defined as +1.