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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Hypertension. 2019 Sep 3;74(4):854–863. doi: 10.1161/HYPERTENSIONAHA.119.12927

Figure 6. Comparison of casein-fed SS/MCW and grain-fed SS/CRL renal T-cells during LS or HS.

Figure 6.

(A) Volcano plot demonstrating significantly up- and downregulated genes (red) when comparing SS/MCW to SS/CRL renal T-cells during LS, and the top 5 DEGs. (B) Functional analysis by IPA of these DEGs showed downregulation of metabolism-related pathways in SS/MCW compared to SS/CRL. (C) Venn diagram of all significant DEGs in kidney T-cells during LS and HS when comparing SS/MCW to SS/CRL rats in each group. (D) Volcano plot demonstrating significantly up- and downregulated genes (red) when comparing SS/MCW to SS/CRL renal T-cells during HS, and the top 5 DEGs. (E) Functional analysis by IPA of these DEGs showed upregulation of inflammatory, T-cell signaling pathways in SS/MCW compared to SS/CRL during HS. (F) Heatmap indicating the activation of migratory and homing mechanisms in the SS/MCW T-cells compared to SS/CRL, which was exacerbated upon HS challenge. n=4 pools/group, 3 rats/pool.