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Effect of L2–L5 epidural RTX (10 μg/ml) or vehicle on A) mean arterial pressure (MAP), and B) heart rate (HR) in 16-week-old SHR rats (n = 6 both groups). C) MAP and HR absolute change from baseline, in response to CSAR stimulation with bradykinin (10 μg/ml). D) TRPV1 immunofluorescence in thoracic (T2–T5) and lumber (L1–L5). Arrow indicates when RTX or Vehicle was administered
