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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: J Orthop Res. 2019 Jun 18;37(10):2130–2137. doi: 10.1002/jor.24353

Figure 3:

Figure 3:

T2-weighted MRI of the left distal femur of miniature pig 1 obtained 18 (panel A), 28 (panel B) and 63 days (Panel C) after surgical interruption of the epiphyseal vascular supply to the abaxial aspect of the medial femoral condyle. White circles mark areas of T2 hyperintensity consistent with epiphyseal cartilage necrosis (panels A to C). Photomicrograph (Panel D) depicting a coronal section through the medial femoral condyle showing an area of epiphyseal cartilage necrosis (dashed line), and associated delay in enchondral ossification (OC manifesta), corresponding with the lesion identified by the white circle in Panel C. Black asterisk marks an area of revascularization within necrotic epiphyseal cartilage. Panel E shows the area indicated by the black rectangle in panel D at twenty times higher magnification. In panel E chondrocyte clones are present at the interface (dashed line) of necrotic (upper half of image) and viable (lower half of image) epiphyseal cartilage. Hematoxylin and eosin stain.