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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Cell Immunol. 2019 Jul 3;344:103949. doi: 10.1016/j.cellimm.2019.103949

Figure 8. Pharmacologic platelet inhibition mediates protection against H1N1 IAV infection in mice.

Figure 8.

Wild-type mice were treated with vehicle (control, white circles), acetylsalicylic acid (ASA, 0.4 mg/mL, black triangles) or clopidogrel (0.15 mg/mL, black squares) in drinking water 3 days prior and after H1N1 IAV infection. A.) Protein levels in BALF of mice treated with vehicle, ASA or clopidogrel before and 7 days after H1N1 IAV infection. Changes in body weights (B) and calculated survival (C) over 14 days after H1N1 IAV infection (N=17 for vehicle, N=15 for ASA and N=8 for clopidogrel). Body weights before infection were set to 100%. Data (mean ± SEM) and calculated survival were analyzed by 2‐way ANOVA (A, B) or log‐rank test (C). * P<0.05, # P<0.05 IAV + ASA versus IAV (vehicle) alone, $ P<0.05 IAV + clopidogrel versus IAV (vehicle) alone.