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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Hypertension. 2019 Sep 3;74(4):957–966. doi: 10.1161/HYPERTENSIONAHA.119.13430

Figure 2:

Figure 2:

Disruptions of the SOD2 gene recapitulate PPHN phenotypes. (A) Flow cytometry analysis plots showing higher apoptosis rates in isolated mouse lung microvascular endothelial cells from sod2−/− compared to WT-mice (n=6). (B) Dual immunofluorescence staining for αSMA (pink), and Ki-67 (green) and DAPI nuclear staining showing increased Ki-67 expression in the remodeled distal-PAs in sod2−/− compared to WT-mice (n=4). (C) Tracings showing elevated right systolic ventricular pressure (RSVP) in sod2−/− compared to WT mice (n=6). Scale bar=100μm.