Table 3.
Hazard ratios and 95% confidence intervals for association of factor scores, eGFR, and ACR (per standard deviation) with risk of cardiovascular disease and heart failure, n=2376
| Kidney measures | Model 1: Demographics + Intervention arm + CVD Risk Factors | Model 2: Model 1 + eGFR + ACR | Model 3: Model 2 + all factors |
|---|---|---|---|
| Cardiovascular Disease (events=306) | |||
| Tubule Injury/Repair Score | 1.25 (1.11 to 1.40) | 1.14 (1.01 to 1.28) | 1.08 (0.95 to 1.23) |
| Tubule Injury/Fibrosis Score | 1.17 (1.03 to 1.33) | 1.07 (0.94 to 1.22) | 1.05 (0.92 to 1.21) |
| Tubule Reabsorption Score | 1.37 (1.23 to 1.54) | 1.18 (1.04 to 1.34) | 1.21 (1.06 to 1.38) |
| Tubular Reserve/Mineral Metabolism Score | 1.35 (1.21 to 1.51) | 1.22 (1.06 to 1.39) | 1.24 (1.08 to 1.42) |
| eGFR (per SD =10.4 ml/min/1.73m2decrease) | 1.29 (1.15 to 1.43) | - | 0.98 (0.85 to 1.13) |
| ACR | 1.44 (1.29 to 1.60) | - | 1.23 (1.08 to 1.40) |
| Heart Failure (events = 123) | |||
| Tubule Injury/Repair Score | 1.36 (1.15 to 1.60) | 1.22 (1.03 to 1.44) | 1.16 (0.96 to 1.40) |
| Tubule Injury/Fibrosis Score | 1.34 (1.07 to 1.67) | 1.18 (0.94 to 1.48) | 1.11 (0.88 to 1.41) |
| Tubule Reabsorption Score | 1.41 (1.18 to 1.68) | 1.11 (0.92 to 1.35) | 1.13 (0.93 to 1.39) |
| Tubular Reserve/Mineral Metabolism Score | 1.62 (1.37 to 1.92) | 1.41 (1.14 to 1.74) | 1.41 (1.13 to 1.74) |
| eGFR (per SD=10.4 ml/min/1.73m2 decrease) | 1.47 (1.24 to 1.75) | - | 1.03 (0.82 to 1.29) |
| ACR | 1.64 (1.39 to 1.94) | - | 1.32 (1.08 to 1.62) |
Demographics: age, sex, race. CVD risk factors: SBP, DBP, number of hypertension medications at baseline, smoking, total cholesterol, HDL cholesterol, statin use, history of CVD or HF. ACR modeled per SD of log2-transformed ACR. Bold indicates p<0.05.