Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2020 Sep 1.

Published in final edited form as: J Inherit Metab Dis. 2019 Apr 8;42(5):934–943. doi: 10.1002/jimd.12088

Figure 2. — A) Sterols were analyzed in the brains from WT and Dhcr24-Het pups derived from either WT or Dhcr24-Het mothers at P0. The maternal phenotype did not affect cholesterol and desmosterol levels in the brain of newborn pups. N for maternal WT genotype: 16 WT pups and 14 Het pups; N for maternal Het genotype: 8 WT pups and 18 Het pups. B) Cholesterol, desmosterol and 7-DHC in different brain regions in WT and Het adult mice at P60. N=4 per group, 2 males and 2 females for each genotype. No sex differences were observed, so males and females of the same genotype were grouped and analyzed together. C) Cholesterol, desmosterol and 7-DHC in brain, spinal cord, sciatic nerve and optic nerve. N=4 per group. Statistical significance for A, B and C: groupwise t-test with Welch’s correction; *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

Figure 2. — A) Sterols were analyzed in the brains from WT and Dhcr24-Het pups derived from either WT or Dhcr24-Het mothers at P0. The maternal phenotype did not affect cholesterol and desmosterol levels in the brain of newborn pups. N for maternal WT genotype: 16 WT pups and 14 Het pups; N for maternal Het genotype: 8 WT pups and 18 Het pups. B) Cholesterol, desmosterol and 7-DHC in different brain regions in WT and Het adult mice at P60. N=4 per group, 2 males and 2 females for each genotype. No sex differences were observed, so males and females of the same genotype were grouped and analyzed together. C) Cholesterol, desmosterol and 7-DHC in brain, spinal cord, sciatic nerve and optic nerve. N=4 per group. Statistical significance for A, B and C: groupwise t-test with Welch’s correction; *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.