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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Hypertension. 2019 Aug 5;74(4):1014–1020. doi: 10.1161/HYPERTENSIONAHA.119.12906

Figure 4.

Figure 4.

Infusion of sPRR impaired autonomous nervous system in obese male mice. (A) Mean arterial pressure response (ΔMAP) to chlorisondamine injection (1mg/kg body weight, i.p) represents the difference in MAP one hour before and one hour after drug injection in HF-fed C57BL/6 male mice infused with vehicle (Veh, n=5) or sPRR (sPRR, n=6). (B) Heart rate response (ΔHR) to propranolol injection (5mg/kg body weight, i.p) represents the difference in HR one hour before and one hour after drug injection. (C) HR response (ΔHR) to atropine injection (5mg/kg body weight, i.p) represents the difference in HR one hour before and one hour after drug injection. Values are mean±SEM. Differences between groups were revealed using One–way ANOVA followed by post hoc Holm-Sidak multiple comparison. *P<0.05 compared with Veh.