. Author manuscript; available in PMC: 2020 Feb 26.

Published in final edited form as: Nat Med. 2019 Aug 26;25(9):1364–1369. doi: 10.1038/s41591-019-0547-7

Table 3. Risk of incident dementia while stratifying participants on both their APOE-related risk and modifiable risk factor profile.

APOE-related risk	Risk factor profile	N/n	HR (95% CI)
Low (ε2ε2/ε2ε3)	Favorable	568/44	Reference
	Intermediate	224/23	1.14 (0.66;1.96)
	Unfavorable	95/18	2.51 (1.40;4.48)
	P for trend		0.0059

Intermediate (ε3ε3)	Favorable	2453/253	Reference
	Intermediate	884/139	1.27 (1.02;1.57)
	Unfavorable	381/64	1.39 (1.04;1.85)
	P for trend		0.0087

High (ε2ε4/ε3ε4/ε4ε4)	Favorable	1132/241	Reference
	Intermediate	443/97	1.00 (0.79;1.28)
	Unfavorable	172/36	1.05 (0.73;1.50)
	P for trend		0.8300

Adjusted for: age, sex and education

Abbreviations: N=number of people at risk, n=number of dementia cases during follow-up, HR=hazard ratio, CI=confidence interval.