Table 3. Risk of incident dementia while stratifying participants on both their APOE-related risk and modifiable risk factor profile.
APOE-related risk | Risk factor profile | N/n | HR (95% CI) |
---|---|---|---|
Low (ε2ε2/ε2ε3) | Favorable | 568/44 | Reference |
Intermediate | 224/23 | 1.14 (0.66;1.96) | |
Unfavorable | 95/18 | 2.51 (1.40;4.48) | |
P for trend | 0.0059 | ||
| |||
Intermediate (ε3ε3) | Favorable | 2453/253 | Reference |
Intermediate | 884/139 | 1.27 (1.02;1.57) | |
Unfavorable | 381/64 | 1.39 (1.04;1.85) | |
P for trend | 0.0087 | ||
| |||
High (ε2ε4/ε3ε4/ε4ε4) | Favorable | 1132/241 | Reference |
Intermediate | 443/97 | 1.00 (0.79;1.28) | |
Unfavorable | 172/36 | 1.05 (0.73;1.50) | |
P for trend | 0.8300 |
Adjusted for: age, sex and education
Abbreviations: N=number of people at risk, n=number of dementia cases during follow-up, HR=hazard ratio, CI=confidence interval.