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. 2018 Jul 14;269(7):867–868. doi: 10.1007/s00406-018-0922-2

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Chemical structure of (R,S)-ketamine, (S)-ketamine (or esketamine) and its metabolite (S)-norketamine. (S)-ketamine is metabolized into (S)-norketamine by the microsomal cytochrome P450 system. The values in parentheses are the inhibitor constant values for NMDAR (10)