| In this population-based, multinational cohort study to evaluate the cardiovascular safety of prucalopride versus polyethylene glycol 3350 (PEG), use of a common protocol and definitions, as well as propensity score (PS) stratification and trimming, yielded comparable study cohorts in four of the five data sources. |
| Differences in reimbursement practices in Germany meant that these analytic methods could not achieve balance for key covariates within the German cohort. |
| Thus, only data from the UK and Sweden (i.e. four of five data sources) were eventually included in the pooled analyses. |
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