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. 2019 Sep 11;9:13125. doi: 10.1038/s41598-019-49485-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of PD-L1_1 on the pathways associated with PD-L1 in tumor cells. Western blotting analyses with the specific antibodies for the indicated proteins of extracts from SK-BR-3 (a) and MDA-MB-231 (b) tumor cells treated in the absence or in the presence of PD-L1_1 or its high affinity variants. Atezolizumab was used as a positive control. A line has been inserted to indicate distant lanes of the same gel (see Supplementary dataset). Protein levels are also expressed as fold increase with respect to those observed in untreated cells and normalized to actin. Error bars depicted means ± SD. P values for the indicated mAbs relative to untreated cells, are: ***P ≤ 0.001; **P < 0.01; *P < 0.05.