Skip to main content
. 2019 Sep 11;10:4131. doi: 10.1038/s41467-019-11998-w

Fig. 3.

Fig. 3

Lack of type I IFN triggering in Spont-PyMT tumors. a Spont-PyMT mice were injected i.p. with DMXAA and then killed after 3 h or 24 h to measure mRNA levels of cytokines and chemokines in tumors. The relative expressions in DMXAA-treated (black diamonds), compared with DMSO-treated (gray diamonds), mice are shown. Each dot corresponds to one tumor. Cumulative data from CTRL: n = 6 mice and DMXAA: n = 6 mice, from three independent experiments, are shown. Tukey’s multiple comparison test. *p < 0.05; **p < 0.01; ***p < 0.001. b, c The relative expression of these cytokines/chemokines, compared with PBS (CTRL) injected mice, were measured in Spont-PyMT (gray circles) and Trans-PyMT (open circles) target lesions 3 h after (b) cGAMP (25 μg i.t.) injection (Spont-PyMT mice: n= 3 CTRL and n= 3 cGAMP; Trans-PyMT mice: n= 5 CTRL and n= 13 cGAMP) or (c) LPS (50 μg i.p.) injection (Spont-PyMT mice: n= 3 CTRL and n= 3 LPS; Trans-PyMT mice: n= 5 CTRL and n= 10 LPS) from three independent experiments. In b and c, the results are expressed as mean ± SEM. Source data are provided as a Source Data file