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. 2019 Sep 11;9:13155. doi: 10.1038/s41598-019-49515-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Indication-Indication association counts plotted as chord diagrams for all Top sets (a–d). Raw association counts are given in Tables S12–S15. These diagrams show predicted relationships between the indications. The width of the chord is proportional to the number of predicted psychoactives relating two indications. Known relationships include Epilepsy with Seizure, Depression with Cocaine-related disorders, etc. Abbreviations used: RLS: Restless leg syndrome, SIMD: sleep initiation and maintenance disorder, ADHD: Attention deficit with hyperactivity disorder, SWS: substance withdrawal syndrome.