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. 2019 Sep 11;10:4108. doi: 10.1038/s41467-019-12124-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Silencing of 2-oxoglutarate dehydrogenase suppresses MCF7 cell growth. a Effects of siRNAs on mRNA expression of 2-oxoglutarate dehydrogenase. siRNAs targeting each subunit of the 2-oxoglutarate dehydrogenase complex (OGDH, DLST, and DLD) were transfected into COX7RP-MCF7 and vector-MCF7 cells. Quantitative RT-PCR analysis of mRNA expression was performed. b Effects of siRNAs on the growth of vector-MCF7 and COX7RP-MCF7 cells under hypoxic (1% O₂) or normoxic conditions. Cell growth was estimated by DNA assay. Data are presented as means ± SD (n = 3 independent experiments). *P < 0.05, **P < 0.01, Student’s t test. Source data are provided as a Source Data file