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SREBP-1 expression and outcome of sorafenib treatment
| SREBP-1 mRNA expression | P | ||
|---|---|---|---|
| High (n = 27) | Low (n = 25) | ||
| TTP | 9.1 | 11.8 | 0.012 |
| 7.7–10.4 (M) | 10.1–13.5 (M) | ||
| OS | 11.3 | 13.7 | 0.024 |
| 9.4–13.1 (M) | 11.6–15.8 (M) | ||
| Overall response rate (CR + PR) | 1 (3.7%) | 3 (12%) | |
| Disease control rate (CR + PR + SD) | 5 (18.5%) | 8 (32%) | |
TTP time to progress, OS overall survival, PR partial remission, CR complete remission, SD stable disease, M months
