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. 2019 Sep 11;9:13088. doi: 10.1038/s41598-019-49409-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The discriminating genes with immune functions and their targets. Panel A shows variants with recognized immune function in the affected subjects. All these genes have been described to exert a pro-inflammatory function (pro-inflammatory genes in black font). Panel B shows variants with recognized immune function identified in the non-affected subjects. Most of these genes exert an immune suppressor function (suppressor genes in green font, pro-inflammatory genes in black font).