Table 1.
Summary of statistical results.
| Fig. 1: Behavioral comparisons | Treatment F (df1,df2), p value |
Time or Exercise Status F (df1,df2), p value |
Interaction (Time × Treatment) F (df1,df2), p value |
| a,1Wheel Revolutions (Fig. 1B) | F1,10 = 3.342, p = 0.0975 | F24,240 = 2.256, p < 0.001 | F24,240 = 0.8518, p = 0.6678 |
| a,2Mechanical Thresholds (Fig. 1C) | F3,20 = 28.25, p < 0.001 | F3,20 = 5.193, p < 0.004 | F15,20 = 4.379, p < 0.001 |
| a,2Cold responsivity (Fig. 1D) | F3,20 = 67.17, p < 0.001 | F3,20 = 36.02, p < 0.001 | F15,20 = 8.432, p < 0.001 |
| Fig. 1: Ki67 and BrdU | Paclitaxel vs. Vehicle | Exercise vs. Sedentary | Interaction |
| aKi67 (Fig. 1E) | F1,18 = 4.116, p = 0.0575 | F1,18 = 4.503, p < 0.05 | F1,18 = 3.113, p = 0.0946 |
| aBrdU (Fig. 1F) | F1,18 = 1.338, p = 0.2625 (Interaction) | F1,18 = 28.83, p < 0.001 | F1,18 = 3.911, p = 0.0635 |
| Fig. 2: Behavioral Comparisons | Treatment | Time or Exercise Status | Interaction |
| a,1Wheel revolutions (Fig. 2B) | F1,10 = 0.079, p = 0.7841 | F22,220 = 8.139, p < 0.001 | F22,220 = 0.5208, p = 0.9638 |
| a,2Mechanical Thresholds (Fig. 2C) | F3,20 = 47.48, p < 0.0001 | F5,20 = 12.87, p < 0.0001 | F15,20 = 3.891, p < 0.0001 |
| a,2Cold Responsivity (Fig. 2D) | F3,20 = 64.33, p < 0.0001 | F5,20 = 47.64, p < 0.0001 | F15,20 = 11.41, p < 0.0001 |
| Fig. 2: Ki67 and BrdU | Paclitaxel vs. Vehicle | Exercise vs. Sedentary | Interaction |
| aKi67 (Fig. 2E) | F1,19 = 0.6380, p = 0.4340 | F1,19 = 0.4785, p = 0.4975 | F1,19 = 0.1684, p = 0.6861 |
| aBrdU (Fig. 2F) | F1,19 = 0.7951, p = 0.3837 | F1,19 = 0.1068, p = 0.7474 | F1,19 = 0.004, p = 0.9841 |
| Fig. 3: Behavioral comparisons | Treatment | Time | Interaction |
| a,3Wheel revolutions (Fig. 3B) | F2,15 = 0.7909, p = 0.4715 | F24,360 = 3.241, p < 0.0001 | F48,360 = 1.278, p = 0.1120 |
| a,4Mechanical thresholds (Fig. 3C) | F1,10 = 7.289, p < 0.023 | F10,10 = 17.07, p < 0.01 | F10,10 = 2.872, p < 0.029 |
| a,4Cold responsivity (Fig. 3D) | F1,10 = 54.30, p < 0.0001 | F7,10 = 30.09, p < 0.001 | F7,10 = 10.91, p < 0.0001 |
|
Fig. 3: Behavioral/ Ki67 and BrdU |
All groups Day 0 vs. Day 15 |
Paclitaxel Ex vs. Paclitaxel S |
|
| bMechanical Thresholds (Fig. 3C) | t11 = 13.25, p < 0.0001 day 15 vs. day 0 mechanical thresholds | ||
| bCold responsivity (Fig. 3D) | t11 = 32.32, p < 0.0001 day 15 vs. day 0 cold responsivity | ||
| cKi67 (Fig. 3E) | t6 = 2.666 df = 6, p < 0.037 | ||
| cBrdU (Fig. 3F) | t6 = 4.567 df = 6, p < 0.003 | ||