. 2019 Sep 11;9:13083. doi: 10.1038/s41598-019-49581-4

Table 3.

Univariate and multivariate analysis of factors prognostic for overall survival in patients with GC.

	Univariate analysis			Multivariate analysis
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Gender (male vs. female)	0.565	0.285–1.12	0.1
Age^a	1.025	0.995–1.06	0.1
Histology (undifferentiated vs. differentiated)	1.018	0.499–2.06	0.96
Tumor size^a	1.122	1.04–1.22	0.005	1.052	0.952–1.16	0.32
Depth of invasion (T2 – T4)	1.305	0.849–2.01	0.23
Lymph node metastasis (N0 – N3)^b	1.982	1.43–2.75	0.0005	2.022	1.43–2.86	0.0006
Lymphatic invasion (Ly0 – Ly3)^c	1.772	1.14–2.77	0.012	1.063	0.627–1.80	0.82
Venous invasion (V0 – V3)^d	0.973	0.639–1.48	0.9
Regulatory B cell (Breg^High vs. Breg^Low)	5.012	2.40–10.45	<0.0001	4.985	2.36–10.54	<0.0001

^aContinuous variables

^bN0: no regional lymph node metastases; N1: Metastasis in 1–2 regional lymph nodes; N2: Metastasis in 3–6 regional lymph nodes; N3; Metastasis in ≥7 regional lymph nodes.

^cLymphatic invasion: Ly0–Ly3, grade of lymphatic invasion.

^dVenous invasion: V0–V3, grade of venous invasion.

See Table 1 for details of histology and depth of invasion.

CI: confidence interval.