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. 2019 Sep 11;9:13122. doi: 10.1038/s41598-019-49583-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the functionalization of Ag NPs and the formation of Ag NPs dimers. (A) Scheme of the Ag NPs functionalization with biotin-HPDP and streptavidin molecules. (B) Scheme of the formation of dimeric nanostructures in the presence of gliadin-specific biotinylated IgG with an interparticle distance of approximately 20 nm (estimated considering the geometry of the IgG antibody and the molecules attached to the Ag NPs).